Supplementary Figure 4: Evaluation of GR metrics in a high-throughput data set. | Nature Methods

Supplementary Figure 4: Evaluation of GR metrics in a high-throughput data set.

From: Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Supplementary Figure 4

(a) Values of IC50 and GR50 (left) and Emax and GRmax (right) for cell cycle drugs evaluated by Heiser et al. Black lines show the median for a given number of divisions, color intensity reflects density of the data points. Undefined and large IC50 and GR50 values are capped at 100 μM for illustration purposes. (b) Values of IC50 and GR50 (left) and Emax and GRmax (right) for 20,000 models of drug response with randomized parameters and numbers of divisions. Black lines show the median for a given number of divisions, color intensity reflects density. Undefined and large IC50 and GR50 values are capped at 30 μM for illustration purposes. (c) Distribution of IC50 and GR50 (left) as well as Emax and GRmax (right) for paclitaxel response in cells grouped by subtype: HER2-amplified (HER2amp), triple-negative breast cancer (TNBC), hormone receptor-positive (HR+), and non-malignant (NM).

Back to article page