Supplementary Figure 2: Modeling toxic drug response and dependence of drug response metrics on division time. | Nature Methods

Supplementary Figure 2: Modeling toxic drug response and dependence of drug response metrics on division time.

From: Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Supplementary Figure 2

(a-c) Simulated data showing relative cell count (green lines) and GR value (purple lines) for partial toxic effect (a), mixed toxic and cytostatic effects (b), or a strong toxic effect (c); see Online Methods for parameter values. The darker the line the longer the division time (Td,, given in days, see legend); note that all GR curves overlap. IC50 and GR50 are projected onto the x-axis, Emax and GRmax onto the y-axis. The subsequent three columns show values of IC50 and GR50 (left), Emax and GRmax (middle), and AUC and GRAOC (right) computed from a theoretical three-day assay with cells dividing at different rates under the same drug response models..

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