Supplementary Figure 1: Modeling drug response and dependence of drug response metrics on division time. | Nature Methods

Supplementary Figure 1: Modeling drug response and dependence of drug response metrics on division time.

From: Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Supplementary Figure 1

(a-b) Simulated data showing relative cell count (green lines) and GR value (purple lines) for a partial cytostatic (a) or cytotoxic (b); see Online Methods for parameter values. The darker the line the longer the division time (Td, given in days, see legend); note that all GR curves overlap. IC50 and GR50 are projected onto the x-axis, Emax and GRmax onto the y-axis. The subsequent three columns show values of IC50 and GR50 (left), Emax and GRmax (middle), and AUC and GRAOC (right) computed from a theoretical three-day assay with cells dividing at different rates under the same drug response models. (c) Values of AUC and GRAOC for a 3 day assay over a range of division times, with drug response model corresponding to Fig. 1g.

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