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Hidden in the mist no more: physical force in cell biology

Nature Methods volume 13, pages 124125 (2016) | Download Citation

To drive its migration through a fibrillar matrix—and thus to spread, invade or metastasize—a cancer cell must exert physical forces. The first visualization of these forces in three dimensions reveals surprising migration dynamics.

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Author information

Affiliations

  1. Karin Wang, Bo Lan and Jeffrey J. Fredberg are at the Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

    • Karin Wang
    • , Bo Lan
    •  & Jeffrey J Fredberg
  2. Li-Heng Cai is at the Harvard School of Engineering and Applied Sciences, Cambridge, Massachusetts, USA.

    • Li-Heng Cai

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Jeffrey J Fredberg.

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DOI

https://doi.org/10.1038/nmeth.3744

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