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Hidden in the mist no more: physical force in cell biology

To drive its migration through a fibrillar matrix—and thus to spread, invade or metastasize—a cancer cell must exert physical forces. The first visualization of these forces in three dimensions reveals surprising migration dynamics.

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Figure 1: Traction stresses generated by a single cell.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Jeffrey J Fredberg.

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Wang, K., Cai, LH., Lan, B. et al. Hidden in the mist no more: physical force in cell biology. Nat Methods 13, 124–125 (2016). https://doi.org/10.1038/nmeth.3744

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