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Diving deeper to predict noncoding sequence function

Nature Methods volume 12, pages 925926 (2015) | Download Citation

The deep learning–based method DeepSEA predicts the molecular function of noncoding DNA polymorphisms.

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References

  1. 1.

    & Nat. Methods 12, 931–934 (2015).

  2. 2.

    Am. J. Hum. Genet. 94, 559–573 (2014).

  3. 3.

    The Neutral Theory of Molecular Evolution (Cambridge University Press, 1983).

  4. 4.

    et al. Genome Res. 15, 901–913 (2005).

  5. 5.

    et al. Genome Res. 15, 1034–1050 (2005).

  6. 6.

    et al. Nat. Genet. 46, 61–64 (2014).

  7. 7.

    ENCODE Project Consortium Nature 489, 57–74 (2012).

  8. 8.

    et al. Nature 507, 455–461 (2014).

  9. 9.

    Roadmap Epigenomics Consortium et al. Nature 518, 317–330 (2015).

  10. 10.

    et al. Nat. Genet. 46, 310–315 (2014).

  11. 11.

    , , & Nat. Genet. 47, 276–283 (2015).

  12. 12.

    , , & Nat. Methods 11, 294–296 (2014).

  13. 13.

    et al. Nat. Genet. 47, 955–961 (2015).

  14. 14.

    , , & Preprint at (2015).

  15. 15.

    et al. Nat. Biotechnol. 30, 265–270 (2012).

Download references

Author information

Affiliations

  1. Barbara E. Engelhardt is at the Department of Computer Science, Center for Statistics and Machine Learning, Princeton University, Princeton, New Jersey, USA.

    • Barbara E Engelhardt
  2. Christopher D. Brown is at the Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

    • Christopher D Brown

Authors

  1. Search for Barbara E Engelhardt in:

  2. Search for Christopher D Brown in:

Competing interests

The authors declare no competing financial interests.

Corresponding authors

Correspondence to Barbara E Engelhardt or Christopher D Brown.

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DOI

https://doi.org/10.1038/nmeth.3604

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