Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

What if stem cells turn into embryos in a dish?

Abstract

Recent studies show that pluripotent stem cells can undergo self-organized development in vitro into structures that mimic the body plan of the post-implantation embryo. Modeling human embryogenesis in a dish opens up new possibilities for the study of early development and developmental disorders, but it may also raise substantial ethical concerns.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Lancaster, M.A. & Knoblich, J.A. Science 345, 1247125 (2014).

    Article  Google Scholar 

  2. van den Brink, S.C. et al. Development 141, 4231–4242 (2014).

    Article  CAS  Google Scholar 

  3. Warmflash, A., Sorre, B., Etoc, F., Siggia, E.D. & Brivanlou, A.H. Nat. Methods 11, 847–854 (2014).

    Article  CAS  Google Scholar 

  4. Hough, S.R. et al. Stem Cell Rep. 2, 881–895 (2014).

    Article  CAS  Google Scholar 

  5. Laslett, A.L. et al. BMC Dev. Biol. 7, 12 (2007).

    Article  Google Scholar 

  6. Zhang, X. et al. Cell Stem Cell 7, 90–100 (2010).

    Article  CAS  Google Scholar 

  7. Irie, N. et al. Cell 160, 253–268 (2015).

    Article  CAS  Google Scholar 

  8. Rivera-Pérez, J.A., Jones, V. & Tam, P.P. Methods Enzymol. 476, 185–203 (2010).

    Article  Google Scholar 

  9. Xing, J., Toh, Y.C., Xu, S. & Yu, H. Sci. Rep. 5, 10038 (2015).

    Article  CAS  Google Scholar 

  10. Tam, P.P. & Loebel, D.A. Nat. Rev. Genet. 8, 368–381 (2007).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Martin F Pera.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Pera, M., de Wert, G., Dondorp, W. et al. What if stem cells turn into embryos in a dish?. Nat Methods 12, 917–919 (2015). https://doi.org/10.1038/nmeth.3586

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.3586

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing