Commentary | Published:

What if stem cells turn into embryos in a dish?

Nature Methods volume 12, pages 917919 (2015) | Download Citation

Abstract

Recent studies show that pluripotent stem cells can undergo self-organized development in vitro into structures that mimic the body plan of the post-implantation embryo. Modeling human embryogenesis in a dish opens up new possibilities for the study of early development and developmental disorders, but it may also raise substantial ethical concerns.

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Author information

Author notes

    • Patrick P Tam

    These authors contributed equally to this work.

Affiliations

  1. Department of Anatomy and Neuroscience, University of Melbourne, Melbourne, Victoria, Australia.

    • Martin F Pera
    •  & Megan Munsie
  2. The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia.

    • Martin F Pera
  3. The Florey Neuroscience and Mental Health Institute, Parkville, Victoria, Australia.

    • Martin F Pera
  4. Department of Health, Ethics & Society, Research Schools Care and Public Health Research Institute and GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

    • Guido de Wert
    •  & Wybo Dondorp
  5. Francis Crick Institute, Mill Hill, London, UK.

    • Robin Lovell-Badge
  6. Department of Anatomy and Embryology, Leiden University Medical Centre, Leiden, The Netherlands.

    • Christine L Mummery
  7. Embryology Unit, Children's Medical Research Institute, Westmead, New South Wales, Australia.

    • Patrick P Tam
  8. Discipline of Medicine, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

    • Patrick P Tam

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Martin F Pera.

About this article

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DOI

https://doi.org/10.1038/nmeth.3586

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