Supplementary Figure 6: Performance of ChIPmentation for low-input samples | Nature Methods

Supplementary Figure 6: Performance of ChIPmentation for low-input samples

From: ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors

Supplementary Figure 6

(a) Genome browser screenshot showing ChIPmentation (“CM”) data for individual biological replicates and different cell input amounts (i.e., 10M, 500k, 100k, and 10k cells). Standard ChIP-seq (“ChIP”) data obtained from 500k (H3K4me3, H3K27me3) or 10 million cells (CTCF, GATA1) are shown as a reference.

(b) Peak overlap (fraction of top-X% peaks in one condition that overlap peaks in the other condition) between ChIPmentation samples obtained for different cell numbers (left) and between biological replicates with the same cell number (right). Lines represent the mean of all points of one factor at one x-axis position.

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