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Chemical biology

A machine to manage modifications

Nature Methods volume 12, pages 598–599 (2015)Cite this article

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An automated platform mass-produces RNAs incorporating a wide variety of precisely positioned chemical alterations.

Nuclear magnetic resonance (NMR) spectroscopy can give researchers a detailed glimpse of small RNA structures, but it quickly runs into trouble with larger RNA molecules. Part of the problem is that RNA is composed of just four chemical building blocks—in contrast to the 20 found in proteins—that are relatively similar in structure, yielding heavily overlapping NMR signals that can be difficult or impossible to interpret.

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References

  1. Liu, Y. et al. Synthesis and applications of RNAs with position-selective labelling and mosaic composition. Nature doi:10.1038/nature14352 (4 May 2015).

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  1. Michael Eisenstein
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Cite this article

Eisenstein, M. A machine to manage modifications. Nat Methods 12, 598–599 (2015). https://doi.org/10.1038/nmeth.3468

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  • DOI: https://doi.org/10.1038/nmeth.3468

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