Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Co-opting CRISPR to deliver functional RNAs

Portions of the CRISPR-Cas9 guide RNA can be reworked to carry functional RNA cargos to genomic loci.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: CRISP-Disp delivers RNA cargos in the cell.

References

  1. Shechner, D.M., Hacisuleyman, E., Younger, S.T. & Rinn, J.L. Nat. Methods 12, 664–670 (2015).

    Article  CAS  Google Scholar 

  2. Jinek, M. et al. Science 337, 816–821 (2012).

    Article  CAS  Google Scholar 

  3. Gilbert, L.A. et al. Cell 154, 442–451 (2013).

    Article  CAS  Google Scholar 

  4. Ryan, O.W. et al. eLife 3, e03703 (2014).

    Article  Google Scholar 

  5. Briner, A.E. et al. Mol. Cell 56, 333–339 (2014).

    Article  CAS  Google Scholar 

  6. Konermann, S. et al. Nature 517, 583–588 (2015).

    Article  CAS  Google Scholar 

  7. Zalatan, J.G. et al. Cell 160, 339–350 (2015).

    Article  CAS  Google Scholar 

  8. Nissim, L., Perli, S.D., Fridkin, A., Perez-Pinera, P. & Lu, T.K. Mol. Cell 54, 698–710 (2014).

    Article  CAS  Google Scholar 

  9. O'Connell, M.R. et al. Nature 516, 263–266 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jacob E Corn.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, PC., Corn, J. Co-opting CRISPR to deliver functional RNAs. Nat Methods 12, 613–614 (2015). https://doi.org/10.1038/nmeth.3452

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.3452

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing