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We thank C. Hammang and V.P. Satagopam for helpful discussions. This work was supported by CSIRO's OCE Science Leader program and its Computational and Simulation Sciences platform, as well as the Alexander von Humboldt Foundation. We gratefully acknowledge the support of Amazon AWS in hosting the Aquaria server and in making PSSH2 available as a public data set.

Author information


  1. Digital Productivity, Commonwealth Scientific and Industrial Research Organisation (CSIRO), Sydney, Australia.

    • Seán I O'Donoghue
    • , Christian Stolte
    •  & Julian Heinrich
  2. Division of Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, Australia.

    • Seán I O'Donoghue
    • , Kenneth S Sabir
    • , Vivian Ho
    •  & Fabian A Buske
  3. School of Molecular Bioscience, The University of Sydney, Sydney, Australia.

    • Seán I O'Donoghue
  4. School of Information Technologies, The University of Sydney, Sydney, Australia.

    • Kenneth S Sabir
  5. Department for Bioinformatics and Computational Biology, Technische Universität München, Munich, Germany.

    • Maria Kalemanov
    • , Benjamin Wellmann
    • , Manfred Roos
    • , Burkhard Rost
    •  & Andrea Schafferhans
  6. Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

    • Nelson Perdigão
  7. Instituto de Sistemas e Robótica, Lisboa, Lisbon, Portugal.

    • Nelson Perdigão
  8. St. Vincent's Clinical School, The University of New South Wales (UNSW), Sydney, Australia.

    • Fabian A Buske


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S.I.O. and A.S. jointly conceived of the project. S.I.O. oversaw the project and wrote the manuscript with contributions from A.S. and K.S.S. Software implementation was led by K.S.S. with contributions from S.I.O., C.S., V.H., N.P., F.A.B. and J.H. Interface design was led by C.S. with contributions from S.I.O. The development of PSSH2, the database underlying Aquaria, was led by A.S. with contributions from M.K., B.W., M.R. and B.R.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Seán I O'Donoghue.

Supplementary information

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    Supplementary texts and figures

    Supplementary Figures 1–3 and Supplementary Methods


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    Supplementary Video 1

    An introduction to using Aquaria

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