Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Toward high-throughput biomechanical phenotyping of single molecules

Two high-throughput single-molecule force spectroscopy platforms expand the reach of this technology for biomechanical molecular phenotyping.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1


  1. Otten, M. et al. Nat. Methods 11, 1127–1130 (2014).

    Article  CAS  Google Scholar 

  2. Sitters, G. et al. Nat. Methods 12, 47–50 (2015).

    Article  CAS  Google Scholar 

  3. Neuman, K.C. & Nagy, A. Nat. Methods 5, 491–505 (2008).

    Article  CAS  Google Scholar 

  4. Müller, D.J. & Dufrene, Y.F. Nat. Nanotechnol. 3, 261–269 (2008).

    Article  Google Scholar 

  5. Maerkl, S.J. & Quake, S.R. Science 315, 233–237 (2007).

    Article  CAS  Google Scholar 

  6. Fordyce, P.M. et al. Nat. Biotechnol. 28, 970–975 (2010).

    Article  CAS  Google Scholar 

  7. Struckmeier, J. et al. Nanotechnology 19, 384020 (2008).

    Article  Google Scholar 

  8. Chiou, P.Y., Ohta, A.T. & Wu, M.C. Nature 436, 370–372 (2005).

    Article  CAS  Google Scholar 

  9. De Vlaminck, I. et al. Nano Lett. 11, 5489–5493 (2011).

    Article  Google Scholar 

  10. Otten, M., Wolf, P. & Gaub, H.E. Lab Chip 13, 4198–4204 (2013).

    Article  CAS  Google Scholar 

  11. Streets, A.M. & Huang, Y. Curr. Opin. Biotechnol. 25, 69–77 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Daniel J Müller.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Alsteens, D., Tay, S. & Müller, D. Toward high-throughput biomechanical phenotyping of single molecules. Nat Methods 12, 45–46 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing