Developments in electrical and optical recording technology are scaling up the size of neuronal populations that can be monitored simultaneously. Light-sheet imaging is rapidly gaining traction as a method for optically interrogating activity in large networks and presents both opportunities and challenges for understanding circuit function.
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Keller, P., Ahrens, M. & Freeman, J. Light-sheet imaging for systems neuroscience. Nat Methods 12, 27–29 (2015). https://doi.org/10.1038/nmeth.3214
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DOI: https://doi.org/10.1038/nmeth.3214
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