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The I-TASSER Suite: protein structure and function prediction

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Figure 1: Flow chart and illustrative examples of I-TASSER Suite for protein structure and function modeling.

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Protein Data Bank


  1. Moult, J., Fidelis, K., Kryshtafovych, A., Schwede, T. & Tramontano, A. Proteins 82 (suppl. 2), 1–6 (2014).

    Article  CAS  Google Scholar 

  2. Haas, J. et al. Database (Oxford) 2013, bat031 (2013).

    Article  Google Scholar 

  3. Roy, A., Kucukural, A. & Zhang, Y. Nat. Protoc. 5, 725–738 (2010).

    Article  CAS  Google Scholar 

  4. Yang, J., Roy, A. & Zhang, Y. Bioinformatics 29, 2588–2595 (2013).

    Article  CAS  Google Scholar 

  5. Yang, J., Roy, A. & Zhang, Y. Nucleic Acids Res. 41, D1096–D1103 (2013).

    Article  CAS  Google Scholar 

  6. Zhang, Y. Proteins 82 (suppl. 2), 175–187 (2014).

    Article  CAS  Google Scholar 

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We are grateful to many of the I-TASSER Suite users whose feedback helped improve the functionality and usability of the programs. The work was supported in part by the US National Science Foundation Career Award (DBI 0746198) and the US National Institute of General Medical Sciences (GM083107, GM084222).

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Y.Z. conceived of the research; J.Y., R.Y., A.R., D.X. and J.P. performed research and created and tested the I-TASSER Suite package; J.Y., R.Y., A.R. and Y.Z. wrote the manuscript.

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Correspondence to Yang Zhang.

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The authors declare no competing financial interests.

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Supplementary Tables 1–3 and Supplementary Methods (PDF 5909 kb)

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Yang, J., Yan, R., Roy, A. et al. The I-TASSER Suite: protein structure and function prediction. Nat Methods 12, 7–8 (2015).

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