The ability to convert somatic cells to induced pluripotent stem cells has immense potential to further our understanding of development and disease mechanisms, and for cellular therapy. Before researchers can achieve these goals, they must expand current methodology to incorporate animal models and quantitative descriptions of the essential phenomena driving reprogramming.
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We thank Y. Miyake for all her administrative support.
S.Y. is a member without salary of the scientific advisory board of iPS Academia Japan.
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Karagiannis, P., Yamanaka, S. The fate of cell reprogramming. Nat Methods 11, 1006–1008 (2014). https://doi.org/10.1038/nmeth.3109
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