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CRISPR snapshots of a gene-editing tool

Nature Methods volume 11, page 365 (2014) | Download Citation

From single-molecule functional studies to atomic-resolution structures, a windfall of data sheds light on the Cas9 mechanism of targeted DNA scission.

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    et al. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science 10.1126/science.1247997 (6 February 2014).

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    et al. Crystal structure of Cas9 in complex with guide RNA and target DNA. Cell 156, 935–949 (2014).

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    et al. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature 507, 62–67 (2014).

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