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MutationTaster2: mutation prediction for the deep-sequencing age

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  1. 1

    Schwarz, J.M., Rödelsperger, C., Schuelke, M. & Seelow, D. Nat. Methods 7, 575–576 (2010).

    CAS  Article  Google Scholar 

  2. 2

    The 1000 Genomes Project Consortium. Nature 491, 56–65 (2012).

  3. 3

    Landrum, M.J. et al. Nucleic Acids Res. 42, D980–D985 (2014).

    CAS  Article  Google Scholar 

  4. 4

    Stenson, P. D. et al. Hum. Genet. 133, 1–9 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Altshuler, D.M. et al. Nature 467, 52–58 (2010).

    CAS  Article  Google Scholar 

  6. 6

    The ENCODE Project Consortium. Nature 489, 57–74 (2012).

  7. 7

    Portales-Casamar, E. et al. Nucleic Acids Res. 38, D105–D110 (2010).

    CAS  Article  Google Scholar 

  8. 8

    Seelow, D., Schwarz, J.M. & Schuelke, M. PLoS ONE 3, e3874 (2008).

    Article  Google Scholar 

Download references


This work is supported by grants from the Deutsche Forschungsgemeinschaft (SFB665 TP-C4) to M.S., the Einsteinstiftung Berlin (A-2011-63) to J.M.S. and M.S. and the German Bundesministerium für Bildung und Forschung (mitoNET 01GM1113D) to D.S. and M.S. M.S. is a member of the NeuroCure Center of Excellence (Exc 257).

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Correspondence to Dominik Seelow.

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D.N.C. receives financial support from BIOBASE GmbH through a license agreement with Cardiff University.

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Supplementary Table 1–3 and Methods (PDF 213 kb)

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Schwarz, J., Cooper, D., Schuelke, M. et al. MutationTaster2: mutation prediction for the deep-sequencing age. Nat Methods 11, 361–362 (2014).

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