Emerging technologies are bringing single-cell genome sequencing into the mainstream; this field has already yielded insights into the genetic architecture and variability between cells that highlight the dynamic nature of the genome.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Microfluidics applications for high-throughput single cell sequencing
Journal of Nanobiotechnology Open Access 11 October 2021
-
Gene expression rearrangements denoting changes in the biological state
Scientific Reports Open Access 19 April 2021
-
Image-Based Single Cell Sorting Automation in Droplet Microfluidics
Scientific Reports Open Access 26 May 2020
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Change history
27 January 2014
In the version of this article initially published, references 16–24 were incorrectly cited as references 15–23. The error has been corrected in the HTML and PDF versions of the article.
References
Flemming, W. Zellsubstanz, Kern und Zelltheilung (Vogel, 1882).
Bridges, C.B. J. Hered. 26, 60–64 (1935).
Hubert, R., MacDonald, M., Gusella, J. & Arnheim, N. Nat. Genet. 7, 420–424 (1994).
Handyside, A.H. et al. N. Engl. J. Med. 327, 905–909 (1992).
Blainey, P.C. FEMS Microbiol. Rev. 37, 407–427 (2013).
Shapiro, E., Biezuner, T. & Linnarsson, S. Nat. Rev. Genet. 14, 618–630 (2013).
Marcy, Y. et al. Proc. Natl. Acad. Sci. USA 104, 11889–11894 (2007).
Marcy, Y. et al. PLoS Genet. 3, 1702–1708 (2007).
Dean, F.B., Nelson, J.R., Giesler, T.L. & Lasken, R.S. Genome Res. 11, 1095–1099 (2001).
Fan, H.C., Wang, J., Potanina, A. & Quake, S.R. Nat. Biotechnol. 29, 51–57 (2011).
Peters, B.A. et al. Nature 487, 190–195 (2012).
Lu, S. et al. Science 338, 1627–1630 (2012).
Arnheim, N., Calabrese, P. & Tiemann-Boege, I. Annu. Rev. Genet. 41, 369–399 (2007).
Wang, J., Fan, H.C., Behr, B. & Quake, S.R. Cell 150, 402–412 (2012).
Lynch, M. Trends Genet. 26, 345–352 (2010).
Zong, C., Lu, S., Chapman, A.R. & Xie, X.S. Science 338, 1622–1626 (2012).
Jan, M. et al. Sci. Transl. Med. 4, 149ra118 (2012).
Shlush, L.I. et al. Blood 120, 603–612 (2012).
Navin, N. et al. Nature 472, 90–94 (2011).
Arendt, T. Mol. Neurobiol. 46, 125–135 (2012).
McConnell, M.J. et al. Science 342, 632–637 (2013).
Evrony, G.D. et al. Cell 151, 483–496 (2012).
Gundry, M., Li, W., Maqbool, S.B. & Vijg, J. Nucleic Acids Res. 40, 2032–2040 (2012).
Martin, S.L. Nature 460, 1087–1088 (2009).
Mastenbroek, S., Twisk, M., van der Veen, F. & Repping, S. Hum. Reprod. Update 17, 454–466 (2011).
Rubio, C. et al. Fertil. Steril. 99, 1400–1407 (2013).
Yang, Z. et al. Mol. Cytogenet. 5, 24 (2012).
Landry Z.C., Giovanonni S.J., Quake S.R. & Blainey P.C. Methods Enzymol. 531, 61–90 (2013).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
P.C.B. holds equity interest in companies in related industries. S.R.Q. is a founder and consultant for Fluidigm Corp., which develops single-cell microfluidics products.
Rights and permissions
About this article
Cite this article
Blainey, P., Quake, S. Dissecting genomic diversity, one cell at a time. Nat Methods 11, 19–21 (2014). https://doi.org/10.1038/nmeth.2783
Published:
Issue Date:
DOI: https://doi.org/10.1038/nmeth.2783
This article is cited by
-
Microfluidics applications for high-throughput single cell sequencing
Journal of Nanobiotechnology (2021)
-
Gene expression rearrangements denoting changes in the biological state
Scientific Reports (2021)
-
Prokaryotic and eukaryotic diversity in hydrothermal continental systems
Archives of Microbiology (2021)
-
Image-Based Single Cell Sorting Automation in Droplet Microfluidics
Scientific Reports (2020)
-
Nanoscale tweezers for single-cell biopsies
Nature Nanotechnology (2019)