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Genomics: the state of the art in RNA-seq analysis

RNA-seq is a recent and immensely popular technology for cataloging and comparing gene expression. Two papers from the international RGASP consortium report on large-scale competitions to identify the best algorithms for RNA-seq analysis, with surprising variability in the results.

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Figure 1

Abigail Yu


  1. Steijger, T. et al. Nat. Methods 10, 1177–1184 (2013).

    CAS  Article  Google Scholar 

  2. Engström, P.G. et al. Nat. Methods 10, 1185–1191 (2013).

    Article  Google Scholar 

  3. Nakamura, K. et al. Nucleic Acids Res. 39, e90 (2011).

    CAS  Article  Google Scholar 

  4. Stanke, M. et al. Nucleic Acids Res. 34, W435–W439 (2006).

    CAS  Article  Google Scholar 

  5. Schweikert, G. et al. Genome Res. 19, 2133–2143 (2009).

    CAS  Article  Google Scholar 

  6. Bradnam, K.R. et al. GigaScience 2, 10 (2013).

    Article  Google Scholar 

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Correspondence to Ian Korf.

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Korf, I. Genomics: the state of the art in RNA-seq analysis. Nat Methods 10, 1165–1166 (2013).

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