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Ethical reproducibility: towards transparent reporting in biomedical research

Optimism about biomedicine is challenged by the increasingly complex ethical, legal and social issues it raises. Reporting of scientific methods is no longer sufficient to address the complex relationship between science and society. To promote 'ethical reproducibility', we call for transparent reporting of research ethics methods used in biomedical research.

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  1. Anderson, J.A., Eijkholt, M. & Illes, J. Nature 487, 432 (2012).

    Article  CAS  Google Scholar 

  2. Macleod, M. Nature 477, 511 (2011).

    Article  Google Scholar 

  3. Hansen, L.A. J. Med. Ethics 39, 188–190 (2012).

    Article  Google Scholar 

  4. Plous, S. & Herzog, H. Science 293, 608–609 (2001).

    Article  CAS  Google Scholar 

  5. Rice, M.J. Philos. Ethics Humanit. Med. 6, 12 (2011).

    Article  Google Scholar 

  6. Stark, A., Tyson, J. & Hibberd, P. J. Perinatol. 30, 163–169 (2010).

    Article  CAS  Google Scholar 

  7. Helfand, B.T. et al. J. Urol. 181, 2674–2679 (2009).

    Article  Google Scholar 

  8. Begg, C. et al. J. Am. Med. Assoc. 276, 637–639 (1996).

    Article  CAS  Google Scholar 

  9. Dingemann, J., Dingemann, C. & Ure, B. Eur. J. Pediatr. Surg. 21, 215–219 (2011).

    Article  CAS  Google Scholar 

  10. Taljaard, M. et al. Br. Med. J. 342, d2496 (2011).

    Article  Google Scholar 

  11. Landis, S.C. et al. Nature 490, 187–191 (2012).

    Article  CAS  Google Scholar 

  12. Kilkenny, C. et al. PLoS ONE 4, e7824 (2009).

    Article  Google Scholar 

  13. Emanuel, E.J. et al. Ann. Intern. Med. 141, 282–291 (2004).

    Article  Google Scholar 

  14. Knoppers, B.M. Health Law Rev. 17, 47 (2009).

    Google Scholar 

  15. Ashcroft, R. & Pfeffer, N. Br. Med. J. 322, 1294–1296 (2001).

    Article  CAS  Google Scholar 

  16. Canadian Council on Animal Care. Policy statement for senior administrators responsible for animal care and use programs. (CCAC, 2008).

  17. Bean, S. et al. IRB 32, 9–12 (2010).

    PubMed  Google Scholar 

  18. McDonald, M. Health Law J. 9, 1–21 (2001).

    CAS  PubMed  Google Scholar 

  19. Eijkholt, M., Anderson, J. A. & Illes, J. Int. J. Law Psychiatry 35, 146–152 (2012).

    Article  Google Scholar 

  20. National Centre for the Replacement, Refinement and Reduction of Animals in Research. Responsibility in the use of animals in bioscience research: expectations of the major research council and charitable funding bodies. (NC3Rs, 2013).

  21. Würbel, H. Nature 446, 257 (2007).

    Article  Google Scholar 

  22. Beauchamp, T.L. & Childress, J.F. Principles of Biomedical Ethics 7th edn. (Oxford University Press, 2012).

    Google Scholar 

  23. Shapin, S. & Schaffer, S. Leviathan and the Air Pump: Hobbes, Boyle, and the Experimental Life (Princeton University Press, 2011).

    Book  Google Scholar 

  24. Gibbons, M. Nature 402, C81–C84 (1999).

    Article  CAS  Google Scholar 

  25. Gunsalus, C.K. et al. Science 312, 1441 (2006).

    Article  CAS  Google Scholar 

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The authors thank M. Cho, Stanford Center for Biomedical Ethics, and R. Cook-Deegan, Director for Genome Ethics, Law & Policy, Duke University, for insightful comments on earlier drafts of this paper. This work was enabled by grants from the Canadian Institutes of Health Research CNE no. 85117, the Canada Research Chairs Program, British Columbia Knowledge Development Fund, Canada Foundation for Innovation, US National Institute of Health–National Institute of Mental Health 9R01MH84282-05 (J.I.) and the Stem Cell Network 9/5251(CT8). This work was conducted at the National Core for Neuroethics, University of British Columbia.

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Correspondence to Judy Illes.

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Anderson, J., Eijkholt, M. & Illes, J. Ethical reproducibility: towards transparent reporting in biomedical research. Nat Methods 10, 843–845 (2013).

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