Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Proteomics

Matching marks with mechanisms

Nature Methods volume 10, pages 604–605 (2013)Cite this article

Subjects

Reagents that recognize specific chemical modifications while ignoring the surrounding protein offer valuable proteomic insights.

Many proteins undergo functional 'fine-tuning' via enzymatic addition and removal of specific chemical groups, a process known as post-translational modification (PTM). Dozens of different PTMs have been identified that affect diverse protein characteristics including localization, stability, activation and so on. By developing 'pan-specific' affinity reagents that recognize target chemical groups in a context-independent fashion, researchers are now getting a better handle on the distribution and function of poorly understood PTMs at the proteomic scale.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Kee, J.-M. et al. A pan-specific antibody for direct detection of protein histidine phosphorylation. Nat. Chem. Biol. doi:10.1038/nchembio.1259 (26 May 2013).

    Article  CAS  Google Scholar 

  2. Moore, K.E. et al. A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol. Cell 50, 444–456 (2013).

    Article  CAS  Google Scholar 

Download references

Authors
  1. Michael Eisenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Eisenstein, M. Matching marks with mechanisms. Nat Methods 10, 604–605 (2013). https://doi.org/10.1038/nmeth.2546

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.2546

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research