Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Panning data for gold: the search for master regulators of cell fate

An approach for analyzing gene expression data identifies putative lineage-specifying transcription factors that may prove useful in cellular reprogramming.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: A computational biology approach to find regulators of cell fate.

Katie Vicari


  1. Heinäniemi, M. et al. Nat. Methods 10, 577–583 (2013).

    Article  Google Scholar 

  2. Spitz, F. & Furlong, E.E. Nat. Rev. Genet. 13, 613–626 (2012).

    Article  CAS  Google Scholar 

  3. Graf, T. & Enver, T. Nature 462, 587–594 (2009).

    Article  CAS  Google Scholar 

  4. Stadtfeld, M. & Hochedlinger, K. Genes Dev. 24, 2239–2263 (2010).

    Article  CAS  Google Scholar 

  5. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  6. Cantor, A.B. & Orkin, S.H. Curr. Opin. Genet. Dev. 11, 513–519 (2001).

    Article  CAS  Google Scholar 

  7. Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).

    Article  CAS  Google Scholar 

  8. Whyte, W.A. et al. Cell 153, 307–319 (2013).

    Article  CAS  Google Scholar 

  9. Neph, S. et al. Cell 150, 1274–1286 (2012).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Matthias Stadtfeld.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Trapkov, V., Stadtfeld, M. Panning data for gold: the search for master regulators of cell fate. Nat Methods 10, 476–477 (2013).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing