Two reports describing the use of direct-conversion electron detectors and algorithms that correct for beam-induced sample motion in single-particle electron cryomicroscopy demonstrate that this technique can solve structures of macromolecules at near-atomic resolution.
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Glaeser, R. Stroboscopic imaging of macromolecular complexes. Nat Methods 10, 475–476 (2013). https://doi.org/10.1038/nmeth.2486
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