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Stroboscopic imaging of macromolecular complexes

Two reports describing the use of direct-conversion electron detectors and algorithms that correct for beam-induced sample motion in single-particle electron cryomicroscopy demonstrate that this technique can solve structures of macromolecules at near-atomic resolution.

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Figure 1: Obtaining high-resolution density maps by single-particle cryo-EM does not require crystals of large, macromolecular structures.

Katie Vicari


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Correspondence to Robert M. Glaeser.

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Glaeser, R. Stroboscopic imaging of macromolecular complexes. Nat Methods 10, 475–476 (2013).

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