An enzymatically dead Cas9 endonuclease permits targeted, RNA-guided transcriptional silencing.
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References
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Qi, L.S. et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell 152, 1173–1183 (2013).
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de Souza, N. CRISPR silencing. Nat Methods 10, 380–381 (2013) doi:10.1038/nmeth.2466
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