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Lost in presumption: stochastic reactions in spatial models

Physical modeling is increasingly important for generating insights into intracellular processes. We describe situations in which combined spatial and stochastic aspects of chemical reactions are needed to capture the relevant dynamics of biochemical systems.

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Figure 1: Different levels of quantitative modeling frameworks for intracellular chemistry.
Figure 2: Examples of combined spatial and stochastic effects in three simple systems.


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This work was supported by the Swedish Research Council (VR), Knut and Alice Wallenberg Foundation (KAW) and European Research Council (ERC). We are grateful for comments on the text from I. Barkefors.

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Correspondence to Johan Elf.

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Mahmutovic, A., Fange, D., Berg, O. et al. Lost in presumption: stochastic reactions in spatial models. Nat Methods 9, 1163–1166 (2012).

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