Physical modeling is increasingly important for generating insights into intracellular processes. We describe situations in which combined spatial and stochastic aspects of chemical reactions are needed to capture the relevant dynamics of biochemical systems.
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Acknowledgements
This work was supported by the Swedish Research Council (VR), Knut and Alice Wallenberg Foundation (KAW) and European Research Council (ERC). We are grateful for comments on the text from I. Barkefors.
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Mahmutovic, A., Fange, D., Berg, O. et al. Lost in presumption: stochastic reactions in spatial models. Nat Methods 9, 1163–1166 (2012). https://doi.org/10.1038/nmeth.2253
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DOI: https://doi.org/10.1038/nmeth.2253
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