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Prevention of overfitting in cryo-EM structure determination

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Figure 1: The prevention of overfitting.

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Acknowledgements

We are grateful to T. Crowther and R. Henderson for helpful discussions and to J. Grimmett for help with computing. T. Crowther provided hepatitis B data, and the National Center for Macromolecular Imaging, which is funded by US National Institutes of Health grant P41RR02250, provided GroEL data. This work was funded by the UK Medical Research Council through grant MC_UP_A025_1013 to S.H.W.S.

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Correspondence to Sjors H W Scheres.

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Scheres, S., Chen, S. Prevention of overfitting in cryo-EM structure determination. Nat Methods 9, 853–854 (2012). https://doi.org/10.1038/nmeth.2115

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