We discuss unique features of lens-free computational imaging tools and report some of their emerging results for wide-field on-chip microscopy, such as the achievement of a numerical aperture (NA) of ∼0.8–0.9 across a field of view (FOV) of more than 20 mm2 or an NA of ∼0.1 across a FOV of ∼18 cm2, which corresponds to an image with more than 1.5 gigapixels. We also discuss the current challenges that these computational on-chip microscopes face, shedding light on their future directions and applications.
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A.O. gratefully acknowledges the support of the Presidential Early Career Award for Scientists and Engineers, Army Research Office Young Investigator Award, National Science Foundation CAREER Award, Office of Naval Research Young Investigator Award and National Institutes of Health Director′s New Innovator Award DP2OD006427 from the Office of the Director, National Institutes of Health.
A.O. is the founder of a start-up company that aims to commercialize optical imaging–based diagnostics tools.
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Greenbaum, A., Luo, W., Su, TW. et al. Imaging without lenses: achievements and remaining challenges of wide-field on-chip microscopy. Nat Methods 9, 889–895 (2012). https://doi.org/10.1038/nmeth.2114
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