Toward objective evaluation of proteomic algorithms

Informatics has driven mass spectrometry–based protein analysis to create large-scale methods for proteomics. As software algorithms have developed, comparisons between algorithms are inevitable. We outline steps for fair and objective comparisons that will make true innovations apparent.

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Acknowledgements

This work was supported by the US National Institutes of Health (P41RR110823, GM103533, R01MH067880, R01DE008921, R2DK09307, RC2DA028845, HHSN268201000035C and P01AG031097 to J.R.Y.; P01AG031097 to S.K.R.P.; R01DE008921, R24DK09307 and RC2DA028845 to C.M.D.; HHSN268201000035C to T.X.; R01MH067880 and F32 AG039127 to J.N.S. and R01MH067880 to D.C.) and DART (SFP-1973 to T.X.)

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Correspondence to John R Yates III.

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