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Close encounters: integrating nanopores and CMOS amplifiers for single-molecule detection

Using semiconductor processing to construct integrated circuits that reside close to nanopores, researchers demonstrate high-bandwidth, low-noise measurements of DNA translocation through solid-state nanopores.

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Figure 1: Schematic of a resistive pulse measurement of DNA translocation through a solid-state nanopore.


  1. Rosenstein, J.K., Wanunu, M., Merchant, C.A., Drndic, M. & Shepard, K.L. Nat. Methods 9, 487–492 (2012).

    Article  CAS  Google Scholar 

  2. Kasianowicz, J.J., Brandin, E., Branton, D. & Deamer, D.W. Proc. Natl. Acad. Sci. USA 93, 13770–13773 (1996).

    Article  CAS  Google Scholar 

  3. Akeson, M., Branton, D., Kasianowicz, J.J., Brandin, E. & Deamer, D.W. Biophys. J. 77, 3227–3233 (1999).

    Article  CAS  Google Scholar 

  4. Meller, A., Nivon, L., Brandin, E., Golovchenko, J. & Branton, D. Proc. Natl. Acad. Sci. USA 97, 1079–1084 (2000).

    Article  CAS  Google Scholar 

  5. Uram, J.D., Ke, K. & Mayer, M. ACS Nano 2, 857–872 (2008).

    Article  CAS  Google Scholar 

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Correspondence to John S Oliver.

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J.S.O. and V.D. are employees of Nabsys Inc.

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Oliver, J., Dimitrov, V. Close encounters: integrating nanopores and CMOS amplifiers for single-molecule detection. Nat Methods 9, 453–454 (2012).

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