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Biomaterials

Thwarting thrombus

A new generation of biocompatible materials may be on the horizon. Building or coating medical devices with materials that release the versatile bioregulatory agent, nitric oxide, can greatly improve their performance when in contact with tissues and physiological fluids.

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Figure 1: Biocompatibility improvement through diazeniumdiolation.
Figure 2: Stopping clot formation with NO-releasing materials.

Photographs are reproduced from Zhang et al.1 with permission.

References

  1. Zhang, H. et al. J. Am. Chem. Soc. 125, 5015–5024 (2003).

    Article  CAS  Google Scholar 

  2. Smith, D.J. et al. J. Med. Chem. 39, 1148–1156 (1996).

    Article  CAS  Google Scholar 

  3. Shabani, M., Pulfer, S.K., Bulgrin, J.P. & Smith, D.J. Wound Repair Regen. 4, 353–362 (1996).

    Article  CAS  Google Scholar 

  4. Schoenfisch, M.H. et al. Anal. Chem. 72, 1119–1126 (2000).

    Article  CAS  Google Scholar 

  5. Bohl, K.S. & West, J.L. Biomaterials 21, 2273–2278 (2000).

    Article  CAS  Google Scholar 

  6. Mowery, K.A., Schoenfisch, M.H., Saavedra, J.E., Keefer, L.K. & Meyerhoff, M.E. Biomaterials 21, 9–21 (2000).

    Article  CAS  Google Scholar 

  7. Nablo, B.J., Chen, T.-Y. & Schoenfisch, M.H. J. Am. Chem. Soc. 123, 9712–9713 (2001).

    Article  CAS  Google Scholar 

  8. Schoenfisch, M.H., Zhang, H., Frost, M.C. & Meyerhoff, M.E. Anal. Chem. 74, 5937–5941 (2002).

    Article  CAS  Google Scholar 

  9. Frost, M.C., Rudich, S.M., Zhang, H., Maraschino, M.A. & Meyerhoff, M.E. Anal. Chem. 74, 5942–5947 (2002).

    Article  CAS  Google Scholar 

  10. Keefer, L.K. Annu. Rev. Pharmacol. Toxicol. 43, 585–607 (2003).

    Article  CAS  Google Scholar 

  11. Morbidelli, L., Donnini, S. & Ziche, M. Curr. Pharm. Design 9, 521–530 (2003).

    Article  CAS  Google Scholar 

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Keefer, L. Thwarting thrombus. Nature Mater 2, 357–358 (2003). https://doi.org/10.1038/nmat913

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