Antimicrobials

Broad-spectrum antivirals

Nanoparticle mimics of heparan sulfate proteoglycans offer a new strategy for the inhibition of a range of viral infections.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Virus lifecycle and intracellular delivery of antiviral agents.
Figure 2: The mechanism of action of virucidal nanoparticles.

References

  1. 1

    Howard, C. R. & Fletcher, N. F. Emerg. Microbes Infect. 1, e46 (2012).

    Google Scholar 

  2. 2

    Plotkin, S. A. Nat. Med. 11, S5–S11 (2005).

    CAS  Article  Google Scholar 

  3. 3

    Cagno, V. et al. Nat. Mater. 17, 195–203 (2018).

    CAS  Article  Google Scholar 

  4. 4

    Wisskirchen, K., Lucifora, J., Michler, T. & Protzer, U. Trends Pharmacol. Sci. 35, 470–478 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Barnhart, M. Glob. Health Sci. Pract. 5, 182–187 (2017).

    Article  Google Scholar 

  6. 6

    Kaufmann, S. H. E., Dorhoi, A., Hotchkiss, R. S. & Bartenschlager, R. Nat. Rev. Drug Discov. 17, 35–56 (2018).

    CAS  Article  Google Scholar 

  7. 7

    Gnanadhas, D. P. et al. J. Clin. Invest. 127, 857–873 (2017).

    Article  Google Scholar 

  8. 8

    Xu, L. et al. Science 358, 85–90 (2017).

    CAS  Article  Google Scholar 

  9. 9

    White, M. K., Hu, W. & Khalili, K. PLoS Pathog. 12, e1005953 (2016).

    Article  Google Scholar 

  10. 10

    Vigant, F., Santos, N. C. & Lee, B. Nat. Rev. Microbiol. 13, 426–437 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Howard E. Gendelman.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Edagwa, B., Gendelman, H. Broad-spectrum antivirals. Nat. Mater. 17, 114–116 (2018). https://doi.org/10.1038/nmat5064

Download citation

Further reading

Search

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing