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Cellular adhesion

Instant integrin mechanosensing

Single-cell force spectroscopy reveals rapid, biphasic integrin activation and reinforcement of cell–matrix bonds during the initial steps of fibroblast adhesion.

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Figure 1: Rapid integrin mechanosensing.

References

  1. Tamkun, J. W. et al. Cell 46, 271–82 (1986).

    CAS  Article  Google Scholar 

  2. Pierschbacher, M. D. & Ruoslahti, E. Nature 309, 30–33 (1984).

    CAS  Article  Google Scholar 

  3. Wang, N., Butler, J. P. & Ingber, D. E. Science 260, 1124–1127 (1993).

    CAS  Article  Google Scholar 

  4. del Rio, A. et al. Science 323, 638–641 (2009).

    CAS  Article  Google Scholar 

  5. Grashoff, C. et al. Nature 466, 263–266 (2010).

    CAS  Article  Google Scholar 

  6. Strohmeyer, N., Bharadwaj, M., Costell, M., Fässler, R. & Müller, D. J. Nat. Mater. 16, 1262–1270 (2017).

    CAS  Article  Google Scholar 

  7. Taubenberger, A. et al. Mol. Biol. Cell 18, 1634–1644 (2007).

    CAS  Article  Google Scholar 

  8. Gingras, A. R. et al. EMBO J. 27, 458–469 (2008).

    CAS  Article  Google Scholar 

  9. Kong, F., García, A. J., Mould, A. P., Humphries, M. J. & Zhu, C. J. Cell Biol. 185, 1275–1284 (2009).

    CAS  Article  Google Scholar 

  10. Seong, J. et al. Proc. Natl Acad. Sci. USA 110, 19372–19377 (2013).

    CAS  Article  Google Scholar 

  11. Na, S. et al. Proc. Natl Acad. Sci. USA 105, 6626–6631 (2008).

    CAS  Article  Google Scholar 

  12. le Duc, Q. et al. J. Cell Biol. 189, 1107–1115 (2010).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Ning Wang.

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Wang, N. Instant integrin mechanosensing. Nature Mater 16, 1173–1174 (2017). https://doi.org/10.1038/nmat5041

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