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Organoids: Modelling polycystic kidney disease

Cysts were generated from organoids in vitro and the removal of adherent cues was shown to play a key role in polycystic kidney disease progression. These cysts resembled those of diseased tissue phenotypically and were capable of remodelling their microenvironment.

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Author information

Affiliations

  1. Paola Romagnani is in the Department of Biomedical and Experimental Sciences 'Mario Serio', and at the Excellence Centre for Research, Transfer and High Education for the development of DE NOVO Therapies (DENOTHE), and the Pediatric Nephrology Unit, Meyer Children's Hospital, University of Florence, 50139 Florence, Italy

    • Paola Romagnani

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Correspondence to Paola Romagnani.