High-resolution imaging, composition analysis and mechanical testing reveal a disordered transitional material within the Achilles tendon-to-bone attachment, structured as a fibrous network to enable force transfer and maximize structural integrity.
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References
Liu, Y. et al. J. R. Soc. Interface 11, 20130835 (2014).
Thurner, P. J., Lam, S., Weaver, J. C., Morse, D. E. & Hansma, P. K. J. Adhesion 85, 526–545 (2009).
Alexander, B. et al. J. R. Soc. Interface 9, 1774–1786 (2012).
Liu, Y., Birman, V., Chen, C., Thomopoulos, S. & Genin, G. M. J. Eng. Mater. Technol. 133, 011006 (2011).
Galatz, L. M., Ball, C. M., Teefey, S. A., Middleton, W. D. & Yamaguchi, K. J. Bone Joint Surg. Am. 86, 219–224 (2004).
Lu, H. H. & Thomopoulos, S. Annu. Rev. Biomed. Eng. 15, 201–226 (2013).
Benjamin, M. et al. Comp. Biochem. Phys. A 133, 931–945 (2002).
Wopenka, B., Kent, A., Pasteris, J. D., Yoon, Y. & Thomopoulos, S. Appl. Spectrosc. 62, 1285–1294 (2008).
Moffat, K. L. et al. Proc. Natl Acad. Sci. USA 105, 7947–7952 (2008).
Genin, G. M. et al. Biophys. J. 97, 976–985 (2009).
Rossetti, L. et al. Nat. Mater. 16, 664–670 (2017).
Schwartz, A. G., Pasteris, J. D., Genin, G. M., Daulton, T. L. & Thomopoulos, S. PLoS One 7, e48630 (2012).
Hu, Y. et al. Biophys. J. 108, 431–437 (2015).
Sarvestani, A. S. & Picu, C. R. Polymer 45, 7779–7790 (2004).
Aghvami, M., Barocas, V. H. & Sander, E. A. J. Biomech. Eng. 135, 071004 (2013).
Ma, X. et al. Biophys. J. 104, 1410–1418 (2013).
Wang, H., Abhilash, A. S., Chen, C. S., Wells, R. G. & Shenoy, V. B. Biophys. J. 107, 2592–2603 (2014).
Liu, Y., Schwartz, A. G., Birman, V., Thomopoulos, S. & Genin, G. M. Biomech. Mod. Mechanobiol. 13, 973–983 (2014).
Buehler, M. J. Nanotechnology 18, 295102 (2007).
Deymier-Black, A. C., Pasteris, J. D., Genin, G. M. & Thomopoulos, S. J. Biomech. Eng. 137, 111005 (2015).
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Genin, G., Thomopoulos, S. Unification through disarray. Nature Mater 16, 607–608 (2017). https://doi.org/10.1038/nmat4906
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DOI: https://doi.org/10.1038/nmat4906
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