Abstract

We report the synthesis and application of an elastic, wearable crosslinked polymer layer (XPL) that mimics the properties of normal, youthful skin. XPL is made of a tunable polysiloxane-based material that can be engineered with specific elasticity, contractility, adhesion, tensile strength and occlusivity. XPL can be topically applied, rapidly curing at the skin interface without the need for heat- or light-mediated activation. In a pilot human study, we examined the performance of a prototype XPL that has a tensile modulus matching normal skin responses at low strain (<40%), and that withstands elongations exceeding 250%, elastically recoiling with minimal strain-energy loss on repeated deformation. The application of XPL to the herniated lower eyelid fat pads of 12 subjects resulted in an average 2-grade decrease in herniation appearance in a 5-point severity scale. The XPL platform may offer advanced solutions to compromised skin barrier function, pharmaceutical delivery and wound dressings.

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Acknowledgements

The authors thank G. Grove and Z. D. Draelos for their helpful discussions and M. Su for her assistance with the in vivo use studies.

Author information

Affiliations

  1. Living Proof, Inc., Cambridge, Massachusetts 02142, USA

    • Betty Yu
    • , Soo-Young Kang
    • , Morgan Pilkenton
    •  & Alpesh Patel
  2. Olivo Laboratories, LLC, Cambridge, Massachusetts 02142, USA

    • Ariya Akthakul
    • , Nithin Ramadurai
    •  & Amir Nashat
  3. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Daniel G. Anderson
    •  & Robert Langer
  4. Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Daniel G. Anderson
    • , R. Rox Anderson
    •  & Robert Langer
  5. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Daniel G. Anderson
    •  & Robert Langer
  6. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Daniel G. Anderson
    •  & Robert Langer
  7. The Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA

    • Fernanda H. Sakamoto
    •  & R. Rox Anderson
  8. Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA

    • Fernanda H. Sakamoto
    • , Barbara A. Gilchrest
    •  & R. Rox Anderson

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Contributions

B.Y., S.-Y.K., F.H.S., B.A.G. and R.R.A. contributed to the design and analysis of the in vivo use studies. A.A., N.R. and M.P. contributed to the design and development of material synthesis and topical formulation. A.A., N.R., M.P., A.N. and D.G.A. contributed to the characterization and analysis of the in vitro mechanical and rheological data. S.-Y.K. supervised the execution of the in vivo use studies. A.P. conducted in vivo Study B. B.Y. and R.L. managed the research efforts. B.Y., A.A., A.N., B.A.G., R.R.A. and R.L. wrote the manuscript with the help of the co-authors.

Competing interests

All of the authors hold a financial interest in Living Proof and/or Olivo Labs.

Corresponding author

Correspondence to Robert Langer.

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DOI

https://doi.org/10.1038/nmat4635

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