Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Arterial calcification

Conscripted by collagen

Nature Materials volume 15, pages 257–258 (2016)Cite this article

Subjects

In atherosclerotic plaques, patterns of calcification — which have profound implications for plaque stability and vulnerability to rupture — are determined by the collagen's content and patterning throughout the plaque.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Effects of fibrous-cap density and disruption on plaque stability, and patterns of calcium deposition in atherosclerotic lesions.
Figure 2: The role of the extracellular matrix in orchestrating multiple physiological processes in health and disease.

References

  1. Libby, P. & Theroux, P. Circulation 111, 3481–3488 (2005).

    Article  Google Scholar 

  2. Criqui, M. H. et al. JAMA 311, 271–278 (2014).

    Article  CAS  Google Scholar 

  3. Ehara, S. et al. Circulation 110, 3424–3429 (2004).

    Article  Google Scholar 

  4. Cheng, S. L. et al. Circ. Res. 117, 142–156 (2015).

    Article  CAS  Google Scholar 

  5. Deng, L. et al. Arterioscler. Thromb. Vasc. Biol. 35, 175–183 (2015).

    Article  CAS  Google Scholar 

  6. Yao, Y. et al. Circ. Res. 113, 495–504 (2013).

    Article  CAS  Google Scholar 

  7. Hutcheson, J. D. et al. Nature Mater. 15, 335–343 (2016).

    Article  CAS  Google Scholar 

  8. Bertazzo, S. et al. Nature Mater. 12, 576–583 (2013).

    Article  CAS  Google Scholar 

  9. Maldonado, N. et al. Am. J. Physiol. Heart Circ. Physiol. 303, H619–H628 (2012).

    Article  CAS  Google Scholar 

  10. Maldonado, N., Kelly-Arnold, A., Laudier, D., Weinbaum, S. & Cardoso, L. Int. J. Cardiovasc. Imaging 31, 1079–1087 (2015).

    Article  Google Scholar 

  11. Otsuka, F., Sakakura, K., Yahagi, K., Joner, M. & Virmani, R. Arterioscler. Thromb. Vasc. Biol. 34, 724–736 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jordan D. Miller is in the Departments of Surgery and of Physiology and Biomedical Engineering, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA,

    Jordan D. Miller

Authors
  1. Jordan D. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jordan D. Miller.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Miller, J. Conscripted by collagen. Nature Mater 15, 257–258 (2016). https://doi.org/10.1038/nmat4587

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat4587

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing