Direct electrical recording and stimulation of neural activity using micro-fabricated silicon and metal micro-wire probes have contributed extensively to basic neuroscience and therapeutic applications; however, the dimensional and mechanical mismatch of these probes with the brain tissue limits their stability in chronic implants and decreases the neuron–device contact. Here, we demonstrate the realization of a three-dimensional macroporous nanoelectronic brain probe that combines ultra-flexibility and subcellular feature sizes to overcome these limitations. Built-in strains controlling the local geometry of the macroporous devices are designed to optimize the neuron/probe interface and to promote integration with the brain tissue while introducing minimal mechanical perturbation. The ultra-flexible probes were implanted frozen into rodent brains and used to record multiplexed local field potentials and single-unit action potentials from the somatosensory cortex. Significantly, histology analysis revealed filling-in of neural tissue through the macroporous network and attractive neuron–probe interactions, consistent with long-term biocompatibility of the device.
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We thank J. Tian for help and discussions on animal surgeries. This study was supported by Air Force Office of Scientific Research and NSSEFF awards (C.M.L.).
The authors declare no competing financial interests.
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Xie, C., Liu, J., Fu, T. et al. Three-dimensional macroporous nanoelectronic networks as minimally invasive brain probes. Nature Mater 14, 1286–1292 (2015). https://doi.org/10.1038/nmat4427
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