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A sunblock based on bioadhesive nanoparticles

Abstract

The majority of commercial sunblock preparations use organic or inorganic ultraviolet (UV) filters. Despite protecting against cutaneous phototoxicity, direct cellular exposure to UV filters has raised a variety of health concerns. Here, we show that the encapsulation of padimate O (PO)—a model UV filter—in bioadhesive nanoparticles (BNPs) prevents epidermal cellular exposure to UV filters while enhancing UV protection. BNPs are readily suspended in water, facilitate adherence to the stratum corneum without subsequent intra-epidermal or follicular penetration, and their interaction with skin is water resistant yet the particles can be removed via active towel drying. Although the sunblock based on BNPs contained less than 5 wt% of the UV-filter concentration found in commercial standards, the anti-UV effect was comparable when tested in two murine models. Moreover, the BNP-based sunblock significantly reduced double-stranded DNA breaks when compared with a commercial sunscreen formulation.

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Figure 1: Comparison of BNP-based sunscreen and commercial sunscreen.
Figure 2: Evaluation of BNP adhesion.
Figure 3: Synthesis and in vitro evaluation of PO/BNPs.
Figure 4: Histology of dorsal mouse skin sections receiving different topical interventions three days after high dose UV (2,160 J m−2).
Figure 5: CPD staining of mouse dorsal epidermal sheets after receiving different topical interventions and UVB irradiation (160 J m−2).
Figure 6: Staining for γH2AX on mouse dorsal epidermal sheets receiving different topical interventions and UVB irradiation (160 J m−2).

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Acknowledgements

We are grateful to Y. Wu, Y. Lu, R. Fan, Y. Pan, T. Xu and T. Kyriakides of Yale University for access to their instruments in their laboratories. We thank E. Quijano and T. Kyriakides for helpful discussions and J. Zhang for technical assistance. This work was supported by NIH grants CA102703, EB000487 and CA149128, Yale School of Medicine Office of Student Research, and the Howard Hughes Medical Research Fellowship.

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Y.D., A.E., J.L., F.Y., M.G. and W.M.S. designed the experiments. Y.D., A.E., F.Y. and J.L. performed the experiments. All the authors were involved in the analyses and interpretation of data. Y.D., A.E., M.G. and W.M.S. wrote the paper, with the help of the co-authors.

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Correspondence to W. Mark Saltzman.

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Deng, Y., Ediriwickrema, A., Yang, F. et al. A sunblock based on bioadhesive nanoparticles. Nature Mater 14, 1278–1285 (2015). https://doi.org/10.1038/nmat4422

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