Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Wound healing

Enzymatically crosslinked scaffolds

Microgel particle precursors bearing peptide substrates for human enzymes crosslink in wound sites to produce bioactive scaffolds in situ that rapidly recruit cells and promote dermal healing.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Strategy for transforming peptide-derivatized microporous annealed particles (MAPs) into robust, cell-infiltrated scaffolds for wound healing.


  1. Ringsdorf, H., Schlarb, B. & Venzmer, J. Angew. Chem. Int. Ed. Engl. 27, 113–158 (1988).

    Article  Google Scholar 

  2. Gale, P. A. & Steed, J. W. (eds) Supramolecular Chemistry: From Molecules to Nanomaterials (Wiley, 2012).

    Book  Google Scholar 

  3. Griffin, D. R., Weaver, W. M., Scumpia, P. O., Di Carlo, D. & Segura, T. Nature Mater. 14, 737–744 (2015).

    CAS  Article  Google Scholar 

  4. Ulijn, R. V. J. Mater. Chem. 16, 2217–2225 (2006).

    CAS  Article  Google Scholar 

  5. Hu, B.-H. & Messersmith, P. B. J. Am. Chem. Soc. 125, 14298–14299 (2003).

    CAS  Article  Google Scholar 

  6. Schense, J. C. & Hubbell, J. A. Bioconj. Chem. 10, 75–81 (1999).

    CAS  Article  Google Scholar 

  7. Sakiyama-Elbert, S. E. & Hubbell, J. A. Annu. Rev. Mater. Res. 31, 183–201 (2001).

    CAS  Article  Google Scholar 

  8. Patterson, J. & Hubbell, J. A. Biomaterials 31, 7836–7845 (2010).

    CAS  Article  Google Scholar 

  9. Lutolf, M. P. Proc. Natl Acad. Sci. USA 100, 5413–5418 (2003).

    CAS  Article  Google Scholar 

  10. Burdick, J. A. & Murphy, W. L. Nature Commun. 3, 1269 (2012).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to David W. Grainger.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Grainger, D. Enzymatically crosslinked scaffolds. Nature Mater 14, 662–663 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing