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DNA–peptide complexes

Regulation of interferon production

DNA spacing within hexagonal bundles of DNA and polycationic peptides correlates with interferon production in dendritic cells.

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Figure 1: DNA/cationic peptide structures.
Figure 2: Normalized concentrations of IFN-α produced by dendritic cells incubated with each of 15 different in vitro reconstituted complexes of DNA and polyvalent cation, as a function of the position of the first peak in the corresponding SAXS profile of the complex.


  1. Wang, S. et al. Cell 160, 785–797 (2015).

    Article  CAS  Google Scholar 

  2. Schmidt, N. W. et al. Nature Mater. 14, 696–700 (2015).

    Article  CAS  Google Scholar 

  3. Hoshino, K. & Kaisho, T. Curr. Opin. Immun. 20, 408–413 (2008).

    Article  CAS  Google Scholar 

  4. Cherstvy, A. G. Phys. Chem. Chem. Phys. 13, 9942–9968 (2011).

    Article  CAS  Google Scholar 

  5. Wong, G. C. L. & Pollack, L. Annu. Rev. Phys. Chem. 61, 171–189 (2010).

    Article  CAS  Google Scholar 

  6. Frenkel, D. & Smit, B. Understanding Molecular Simulation: From Algorithms to Applications (Elsevier, 2001).

    Google Scholar 

Download references

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Correspondence to William M. Gelbart.

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Gelbart, W. Regulation of interferon production. Nature Mater 14, 661–662 (2015).

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