Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cell mechanics

Auxetic nuclei

The nuclei of naive mouse embryonic stem cells that are transitioning towards differentiation expand when the cells are stretched and contract when they are compressed. What drives this auxetic phenotype is, however, unclear.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: The nucleus of an embryonic stem cell in the transition state expands when stretched.


  1. Pagliara, S. et al. Nature Mater. 13, 638–644 (2014).

    Article  CAS  Google Scholar 

  2. Guck, J. et al. Biophys. J. 81, 767–784 (2001).

    Article  CAS  Google Scholar 

  3. Harada, T. et al. J. Cell Biol. 204, 669–682 (2014).

    Article  CAS  Google Scholar 

  4. Swift, J. et al. Science 341, 1240104 (2013).

    Article  Google Scholar 

  5. Guilluy, C. et al. Nature Cell Biol. 16, 376–381 (2014).

    Article  CAS  Google Scholar 

  6. Schwarz, B. A., Bar-Nur, O., Silva, J. C. & Hochedlinger, K. Curr. Biol. 24, 347–350 (2014).

    Article  CAS  Google Scholar 

  7. Discher, D. E., Mooney, D. J. & Zandstra, P. W. Science 324, 1673–1677 (2009).

    Article  CAS  Google Scholar 

  8. Poh, Y. C., Chowdhury, F., Tanaka, T. S. & Wang, N. Biophys. J. 99, L01–L03 (2010).

    Article  Google Scholar 

  9. Chowdhury, F. et al. Nature Mater. 9, 82–88 (2010).

    Article  CAS  Google Scholar 

  10. Campàs, O. et al. Nature Methods 11, 183–189 (2014).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ning Wang.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, N. Auxetic nuclei. Nature Mater 13, 540–542 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing