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Cancer imaging

Lighting up tumours

Detection of a wide range of tumours remains a challenge in cancer diagnostics. By exploiting changes in the tumour microenvironment, a pH-responsive polymeric nanomaterial enables ultrasensitive tumour-specific imaging in many types of cancer.

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Figure 1: A schematic representation of pH-sensitive imaging of the tumour microenvironment using ultra-pH-sensitive nanoprobes2.

References

  1. Gerlinger, M. et al. N. Engl. J. Med. 366, 883–892 (2012).

    CAS  Article  Google Scholar 

  2. Wang, Y. et al. Nature Mater. 13, 204–212 (2014).

    CAS  Article  Google Scholar 

  3. Trédan, O., Galmarini, C. M., Patel, K. & Tannock, I. F. J. Natl Cancer Inst. 99, 1441–1454 (2007).

    Article  Google Scholar 

  4. Wang, R. et al. Nature 468, 829–833 (2010).

    CAS  Article  Google Scholar 

  5. Roberts, W. G. & Palade, G. E. Cancer Res. 57, 765–772 (1997).

    CAS  Google Scholar 

  6. Matsumura, Y. & Maeda, H. Cancer Res. 46, 6387–6392 (1986).

    CAS  Google Scholar 

  7. Mura, S., Nicolas, J. & Couvreur, P. Nature Mater. 12, 991–1003 (2013).

    CAS  Article  Google Scholar 

  8. Zhou, K. et al. J. Am. Chem. Soc. 134, 7803–7811 (2012).

    CAS  Article  Google Scholar 

  9. Ntziachristos, V. et al. Nature Biotechnol. 23, 313–320 (2005).

    CAS  Article  Google Scholar 

  10. Kim, J., Piao, Y. & Hyeon, T. Chem. Soc. Rev. 38, 372–390 (2009).

    CAS  Article  Google Scholar 

  11. Dagmar, F. et al. Biomaterials 7, 1121–1131 (2003).

    Google Scholar 

Download references

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Correspondence to Taeghwan Hyeon.

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Ling, D., Hackett, M. & Hyeon, T. Lighting up tumours. Nature Mater 13, 122–124 (2014). https://doi.org/10.1038/nmat3860

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