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Cellular mechanosensing

Sharing the force

Cells can sense their environment by applying and responding to mechanical forces, yet how these forces are transmitted through the cell's cytoskeleton is largely unknown. Now, a combination of experiments and computer simulations shows how forces applied to the cell cortex are synergistically shared by motor proteins and crosslinkers.

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Figure 1: Schematic of the micropipette-aspiration experiment6.

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Correspondence to Andreas R. Bausch or Ulrich S. Schwarz.

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Bausch, A., Schwarz, U. Sharing the force. Nature Mater 12, 948–949 (2013). https://doi.org/10.1038/nmat3791

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