Precision thermometry of the skin can, together with other measurements, provide clinically relevant information about cardiovascular health, cognitive state, malignancy and many other important aspects of human physiology. Here, we introduce an ultrathin, compliant skin-like sensor/actuator technology that can pliably laminate onto the epidermis to provide continuous, accurate thermal characterizations that are unavailable with other methods. Examples include non-invasive spatial mapping of skin temperature with millikelvin precision, and simultaneous quantitative assessment of tissue thermal conductivity. Such devices can also be implemented in ways that reveal the time-dynamic influence of blood flow and perfusion on these properties. Experimental and theoretical studies establish the underlying principles of operation, and define engineering guidelines for device design. Evaluation of subtle variations in skin temperature associated with mental activity, physical stimulation and vasoconstriction/dilation along with accurate determination of skin hydration through measurements of thermal conductivity represent some important operational examples.
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Wang, S. D. et al. Mechanics of epidermal electronics. J. Appl. Mech.-T. ASME 79, 031022 (2012).
Kim, D. H. et al. Epidermal electronics. Science 333, 838–843 (2011).
Arumugam, V., Naresh, M. D. & Sanjeevi, R. Effect of strain rate on the fracture behaviour of skin. J. Biosci. 19, 307–313 (1994).
Agache, P. G., Monneur, C., Leveque, J. L. & De Rigal, J. Mechanical properties and Young’s modulus of human skin in vivo. Arch. Dermatol. Res. 269, 221–232 (1980).
Cohen, M. L. Measurement of thermal-properties of human-skin—review. J. Invest. Dermatol. 69, 333–338 (1977).
Hassan, M. & Togawa, T. Observation of skin thermal inertia distribution during reactive hyperaemia using a single-hood measurement system. Physiol. Meas. 22, 187–200 (2001).
Thoresen, M. & Walloe, L. Skin blood-flow in humans as a function of environmental-temperature measured by ultrasound. Acta Physiol. Scand. 109, 333–341 (1980).
Lossius, K., Eriksen, M. & Walloe, L. Fluctuations in blood-flow to acral skin in humans—connection with heart-rate and blood-pressure variability. J. Physiol. 460, 641–655 (1993).
Crandall, C. G., Meyer, D. M., Davis, S. L. & Dellaria, S. M. Palmar skin blood flow and temperature responses throughout endoscopic sympathectomy. Anesth. Anal. 100, 277–283 (2005).
Jansky, L. et al. Skin temperature changes in humans induced by local peripheral cooling. J. Therm. Biol. 28, 429–437 (2003).
Bernjak, A., Clarkson, P. B., McClintock, P. V. & Stefanovska, A. Low-frequency blood flow oscillations in congestive heart failure and after beta1-blockade treatment. Microvasc. Res. 76, 224–232 (2008).
Holowatz, L. A., Thompson-Torgerson, C. S. & Kenney, W. L. The human cutaneous circulation as a model of generalized microvascular function. J. Appl. Physiol. 105, 370–372 (2008).
Gorbach, A. M. et al. Infrared imaging of nitric oxide-mediated blood flow in human sickle cell disease. Microvasc. Res. 84, 262–269 (2012).
Kvandal, P. et al. Low-frequency oscillations of the laser Doppler perfusion signal in human skin. Microvasc. Res. 72, 120–127 (2006).
Ishibashi, Y. et al. Short duration of reactive hyperemia in the forearm of subjects with multiple cardiovascular risk factors. Circ. J. 70, 115–123 (2006).
Huang, A. L. et al. Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery. Arterioscler. Thromb. Vasc. 27, 2113–2119 (2007).
Nordin, M. Sympathetic discharges in the human supraorbital nerve and their relation to sudo- and vasomotor responses. J. Physiol. 423, 241–255 (1990).
Celermajer, D. S. et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340, 1111–1115 (1992).
Akhtar, M. W., Kleis, S. J., Metcalfe, R. W. & Naghavi, M. Sensitivity of digital thermal monitoring parameters to reactive hyperemia. J. Biomech. Eng. 132, 051005 (2010).
Deshpande, C. Thermal Analysis of Vascular Reactivity. MS thesis, Texas A&M Univ. (2007).
Gustafsson, S. E. Transient plane source techniques for thermal conductivity and thermal diffusivity measurements of solid materials. Rev. Sci. Instrum. 62, 797–804 (1991).
Park, J. H., Lee, J. W., Kim, Y. C. & Prausnitz, M. R. The effect of heat on skin permeability. Int. J. Pharm. 359, 94–103 (2008).
Paranjape, M. et al. A PDMS dermal patch for non-intrusive transdermal glucose sensing. Sens. Actuat. A 104, 195–204 (2003).
Ikeda, T. et al. Local radiant heating increases subcutaneous oxygen tension. Am. J. Surg. 175, 33–37 (1998).
This material is based on work supported by the National Science Foundation under Grant No. DGE-1144245, Grant No. ECCS-0824129 and through the Materials Research Laboratory and Center for Microanalysis of Materials at the University of Illinois at Urbana-Champaign. J.A.R. acknowledges financial support through a National Security Science and Engineering Faculty Fellowship. The work on silicon nanomembranes was financially supported by a MURI grant from the Air Force Office of Scientific Research. This research was supported in part by the Intramural Research Program of NIBIB, NIH. The authors would like to thank H. Eden for his invaluable critique and insightful comments during preparation of this manuscript.
The authors declare no competing financial interests.
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Webb, R., Bonifas, A., Behnaz, A. et al. Ultrathin conformal devices for precise and continuous thermal characterization of human skin. Nature Mater 12, 938–944 (2013). https://doi.org/10.1038/nmat3755
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