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Cell migration

Towards the void

Cells at the edges of migrating epithelial sheets pull themselves towards unfilled space regardless of their direction of motion.

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Figure 1: Colour maps of traction forces exerted on an underlying elastic substrate by a migrating cell sheet approaching and surrounding a non-adhesive island (values are averages of six identical cell sheets)3.
Figure 2: Heterogeneity in cell shape within a migrating cell sheet downstream of a non-adhesive island3.


  1. Rorth, P. Annu. Rev. Cell Dev. Biol. 25, 407–429 (2009).

    Article  CAS  Google Scholar 

  2. Ridley, A. J. et al. Science 302, 1704–1709 (2003).

    Article  CAS  Google Scholar 

  3. Kim, J. H. et al. Nature Mater. 12, 856–863 (2013).

    Article  CAS  Google Scholar 

  4. Tambe, D. T. et al. Nature Mater. 10, 469–475 (2011).

    CAS  Google Scholar 

  5. Du Roure, O. et al. Proc. Natl Acad. Sci. USA 102, 2390–2395 (2005).

    Article  CAS  Google Scholar 

  6. Mertz, A. F. Phys. Rev. Lett. 108, 198101 (2012).

    Article  Google Scholar 

  7. Ramaswamy, S. Annu. Rev. Condens. Matter Phys. 1, 323–345 (2010).

    Article  Google Scholar 

  8. Sanchez, T. et al. Nature 491, 431–434 (2012).

    Article  CAS  Google Scholar 

  9. Ouyang, M. et al. Nature Commun. 4, 1589 (2013).

    Article  Google Scholar 

  10. Weber, G. F., Bjerke, M. A. & DeSimone, D. W. Dev. Cell 22, 104–115 (2012).

    Article  CAS  Google Scholar 

  11. Broussard, J. A., Webb, D. J. & Kaverina, I. Curr. Opin. Cell Biol. 20, 85–90 (2008).

    Article  CAS  Google Scholar 

  12. Boettiger, D. Curr. Opin. Cell. Biol. 24, 592–599 (2012).

    Article  CAS  Google Scholar 

  13. Twiss, F. & de Rooij, J. Cell. Mol. Life Sci. (2013).

Download references

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Correspondence to Eric R. Dufresne or Martin A. Schwartz.

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Dufresne, E., Schwartz, M. Towards the void. Nature Mater 12, 783–784 (2013).

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