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Bioengineering and regenerative medicine

Keeping track

Assessing when cell death occurs following in vivo transplantation of stem cells is challenging. Now, pH-sensitive hydrogel capsules containing arginine-based liposomes are shown to act as magnetic resonance imaging contrast agents, allowing cell death to be monitored within the capsules.

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Figure 1: A schematic of the structure of the LipoCEST microcapsules.
Figure 2: The CEST contrast mechanism.

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Correspondence to Sanjiv S. Gambhir.

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Ziv, K., Gambhir, S. Keeping track. Nature Mater 12, 180–181 (2013). https://doi.org/10.1038/nmat3579

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