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Nanoparticle immunotherapy

Combo combat

Nanoparticle-enabled, sustained delivery of soluble hydrophilic cytokines and hydrophobic inhibitors engages the innate and adaptive immune systems to fight cancer.

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Figure 1: The synthesis and biodegradation of nanolipogels.
Figure 2: The immunosuppressive tumour microenvironment and mechanism of action of nanolipogels.

References

  1. Halford, B. Chem. Eng. News 90, 10–15 (2012).

    Google Scholar 

  2. Flavell, R. A., Sanjabi, S., Wrzesinski, S. H. & Licona-Limón, P. Nature Rev. Immunol. 10, 554–567 (2010).

    Article  CAS  Google Scholar 

  3. Smyth, M. J. et al. J. Immunol. 176, 1582–1587 (2006).

    Article  CAS  Google Scholar 

  4. Wrzesinski, S. H., Wan, Y. Y., Flavell, R. A. Clin. Cancer Res. 13, 5262–5270 (2007).

    Article  CAS  Google Scholar 

  5. Acquavella, N. et al. J. Immunother. 31, 569–576 (2008).

    Article  CAS  Google Scholar 

  6. Park, J. et al. Nature Mater. 11, 895–905 (2012).

    Article  CAS  Google Scholar 

  7. Shi, J., Votruba, A. R., Farokhzad, O. C. & Langer, R. Nano Lett. 10, 3223–3230 (2010).

    Article  CAS  Google Scholar 

  8. Torchilin, V. P. Nature Rev. Drug Discov. 4, 145–160 (2005).

    Article  CAS  Google Scholar 

  9. Kano, M. R. et al. Proc. Natl Acad. Sci. USA 104, 3460–3465 (2007).

    Article  CAS  Google Scholar 

  10. Meng, H. et al. ACS Nano 4, 4539–4550 (2010).

    Article  CAS  Google Scholar 

  11. Ashley, C. E. et al. Nature Mater. 10, 389–397 (2011).

    Article  CAS  Google Scholar 

  12. Meng, H. et al. J. Am. Chem. Soc. 132, 12690–12697 (2010).

    Article  CAS  Google Scholar 

  13. Carvalho, L. V. et al. Vaccine 28, 7829–7836 (2010).

    Article  CAS  Google Scholar 

  14. Von Maltzahn, G. et al. Nature Mater. 10, 545–552 (2011).

    Article  CAS  Google Scholar 

Download references

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Correspondence to C. Jeffrey Brinker.

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Brinker, C. Combo combat. Nature Mater 11, 831–832 (2012). https://doi.org/10.1038/nmat3434

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