Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell culture

Soft gels select tumorigenic cells

Pliable gels of fibrin, a fibrous protein involved in blood clotting and linked to cancer, select cells with high in vivo aggressiveness and 'stemness' from a pool of cancer cells.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1

References

  1. Liu, J. et al. Nature Mater. 11, 734–741 (2012).

    CAS  Article  Google Scholar 

  2. Lapidot, T. et al. Nature 367, 645–648 (1994).

    CAS  Article  Google Scholar 

  3. Quintana, E. et al. Nature 456, 593–598 (2008).

    CAS  Article  Google Scholar 

  4. Soofi, S. S., Last, J. A., Liliensiek, S. J., Nealey, P. F. & Murphy, C. J. J. Struct. Biol. 167, 216–219 (2009).

    CAS  Article  Google Scholar 

  5. Engler, A. J., Sen, S., Sweeney, H. L. & Discher, D. E. Cell 126, 677–689 (2006).

    CAS  Article  Google Scholar 

  6. Murrell, M., Kamm, R. & Matsudaira, P. Biophys. J. 101, 297–306 (2011).

    CAS  Article  Google Scholar 

  7. Trappmann, B. et al. Nature Mater. 11, 642–649 (2012).

    CAS  Article  Google Scholar 

  8. Engler, A. J. et al. J. Cell Biol. 166, 877–887 (2004).

    CAS  Article  Google Scholar 

  9. Gilbert, P. M. et al. Science 329, 1078–1081 (2010).

    CAS  Article  Google Scholar 

  10. Winer, J. P., Janmey, P. A., McCormick, M. E. & Funaki, M. Tissue Eng. Part A 15, 147–154 (2009).

    CAS  Article  Google Scholar 

  11. Shin, J. W., Swift, J., Spinler, K. R. & Discher, D. E. Proc. Natl Acad. Sci. USA 108, 11458–11463 (2011).

    CAS  Article  Google Scholar 

  12. Chowdhury, F. et al. Nature Mater. 9, 82–88 (2009).

    Article  Google Scholar 

  13. Paszek, M. J. et al. Cancer Cell 8, 241–254 (2005).

    CAS  Article  Google Scholar 

  14. Brown, A. E., Litvinov, R. I., Discher, D. E., Purohit, P. K. & Weisel, J. W. Science 325, 741–744 (2009).

    CAS  Article  Google Scholar 

  15. Hu, Y. & Smyth, G. K. J. Immunol. Methods 347, 70–78 (2009).

    CAS  Article  Google Scholar 

  16. Kakkar, A. K. & Macbeth, F. Br. J. Cancer 102, S24–S29 (2010).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Dennis E. Discher.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Shin, JW., Discher, D. Soft gels select tumorigenic cells. Nature Mater 11, 662–663 (2012). https://doi.org/10.1038/nmat3388

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmat3388

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer