Enzyme-modified plasmonic nanoparticles that generate a signal that is larger when the concentration of the target molecule is lower can detect ultralow levels of the cancer biomarker prostate-specific antigen in whole serum.
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Käll, M. Inverse sensitivity. Nature Mater 11, 570–571 (2012). https://doi.org/10.1038/nmat3365
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DOI: https://doi.org/10.1038/nmat3365
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